In most cases, patients with these allergies are advised to be on the lookout for products that have given names like Methyl Glycol, Propane-1, 2-Diol, 1,2 Propanediol,1,2 Dihydroxypropane, 2 Hydroxypropyl, Trimethyl Glycol which typically signifies PG. This is a site where you can find resources and share your experience living a life free of glycol compounds. 2005; Yahwak et al. This test was negative. A total of 30% of the positive reactions to PG were allergic in appearance. 2000; Yorgin et al. Bethesda, MD 20894, Web Policies Excessively large or rapidly infused intravenous injections of propylene glycol-containing medications (Horinek et al. WebHere are a few facts about polyethylene glycol (the somewhat dangerous one): Polyethylene glycol is, in fact, used in antifreeze because it lowers the freezing DermNet does not provide an online consultation service.If you have any concerns with your skin or its treatment, see a dermatologist for advice. This is not an easy task; the key significance of propylene glycol sensitivity rests in how ubiquitous the substance is. WebPropylene glycol and Dipropylene glycol are derived from the same chemical process, adding water to propylene oxide. 2007), Refractory hypotension (Wilson et al. Their chemical formula is HO (CH2 CH2) OH. In 24% of cases, the allergy manifests as a generalized/scattered pattern. 2010). Show This to Your Doctor: Proof of Glycol Allergies, 11 Ways to Make Your Life With Glycol Allergies Easier, Resources for Finding Trade Names & Synonyms, Is it PEG? Their molecular weights varied from 200 to 700 Da in a liquid form to 10006000 Da in a solid form, according to the condensation degree. Polyethylene glycols (PEGs) or macrogols are hydrophilic substances used in many drugs and cosmetics. Polyethylene Glycol is made by polymerising ethylene glycol, the main ingredient in antifreeze solutions, and has a strong presence in the medical industry. A 58-year-old man consulted for an anaphylactic shock in 2002 30 min after oral intake of citrate de betaine UPSA effervescent tablets (UPSA, Agen, France) for dyspepsia. Medical content developed and reviewed by the leading experts in allergy, asthma and immunology. Propylene glycol derivatives are potential cross-reactors; further testing is needed. Case report We report on a Caucasian patient experiencing recurrent severe allergic reactions to She tolerates cow`s milk. Phil Lieberman, M.D. 2010), Prolonged dermal contact during treatment of burns (Peleg et al. 2010). Created for people with ongoing healthcare needs but benefits everyone. The second reaction, she had nasal symptoms on that day. 2018 Mar;78(3):211-215. doi: 10.1111/cod.12931. 4. Allergy 2008; 63(4):478-487. The maximal plasma concentrations in humans occur within 1 hour after ingestion. The maximum daily dose of drug for a pediatric patient can be extrapolated from the adult data (based on a 70-kg patient) (Lim et al. Without an awareness of this allergy and how it would present, affectedpatients are potentially at risk of anaphylaxis from a wide variety of medications, in a wide number of settings. 2000), Renal dysfunction (e.g., increased serum creatinine concentrations, proximal renal tubular cell injury, etc.) This year, the winner is an ingredient common to many cosmetics, topical skin products, foods, and medications. I believe what youre saying in #6 is that PG/PEG allergy sufferers may not have a problem with Their chemical formula is HO (CH2 CH2) OH. About 45% of an absorbed propylene glycol dose is excreted unchanged by the kidneys or as the glucuronide conjugate. Our patient had immediate reactions both to weak and high-molecular weight PEGs, which is not usual. Whether severe or mild allergy the patient is advised to use PG free products and avoid all the goods with PG even if in the vicinity there are no other alternatives. Polyethylene glycols of weak molecular weight (200400 Da) have a greater sensitization capacity (1). 3. Theres been quite a bit of research into PG, and the results are not comforting. Even at relatively low concentrations, exposure toPG has been proven to cause irritation and allergic reaction. One report even shows that exposure to PG can cause skin, liver, and kidney damage. Jacqueline A. Pongracic, MD, FAAAAI. Most patients have got alternatives to these commodities. Dermatitis. All Rights Reserved. Copy edited by Gus Mitchell. They are quite different although with similar sounding names. 7/17/2019 Around 38% of products in the American Contact Dermatitis Society Contact Allergen Management Program (CAMP) database at 2016 contain propylene glycol. WebThat's exactly why I'm asking this, a family member is allergic to propylene glycol and I wanted to know if there would be a risk in getting a vaccine with polyethylene glycol in it. Even ingestion is possible (in reasonable amounts) as they can be used in laxatives. Disclaimer, National Library of Medicine My question was allergy to Propylene Glycol not to polyethylene glycol. Even though no specific medical attention has been developed, patients should seek medical care when like four or more of the above symptoms are portrayed. The .gov means its official. Dr. Stone and colleagues used skin testing and oral challenges with PEG and polysorbate-containing agents to determine clinical reactivity and cross-reactivity between the two allergens. Phil Lieberman, M.D. 1,2 There are no reports upon literature review of IgE-mediated or anaphylactic reactions to PG. It was immediately clear that these patients were truly allergicwhen they had strongly positive skin teststo polyethylene glycol 3350 in the form of Miralax, to steroids containing the same ingredient and to steroids containingpolysorbate 80, says Dr. Stone. Dermatitis. Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers found in everyday products such as foods, cosmetics, and medications. Its chemical structure is CH 3 CH [OH]CH 3 OH. Medical content developed and reviewed by the leading experts in allergy, asthma and immunology. However, the osmolar gap, anion gap, and lactate are commonly elevated in propylene glycol intoxication (Lim et al. Patch testing with the European standard series, corticosteroid series and the used topical drugs were all negative at 30 min, 48 and 72 h (except Myroxylon Pereirae and fragrance mix with a past relevance). other applications (smoke screen, smoke simulator, etc.). 1998). Allergy to macrogols (polyethylene glycol) This is a hypertensive reaction of the body either moderately or severely to Propylene-glycol which is a thick oily liquid Following these results, we first realized prick test with PEG 300 and 1500 MW ointment (Trolab, Germany) which is usually used for patch testing. You may need to check with your pharmacist or doctor which topical and other medications will be suitable for you. 2016; 46(7): 907-922. As with other contact allergies, once propylene glycol has been identified as a culprit allergen, education and avoidance are the cornerstone of treatment. Their chemical structures differ by only one methyl group (ethylene glycol = HOCH 2 CH 2 OH; propylene glycol = CH 3 CH [OH]CH 2 OH). 1998), Patients with less effective or impaired alcohol dehydrogenase enzyme systems (e.g., children younger than 4 years, pregnant women, patients with hepatic disease, and patients treated with disulfiram or metronidazole), Burn patients who receive extensive dermal applications of propylene glycol, Hyperosmolality and an anion gap metabolic acidosis, often accompanied by acute kidney injury, and potential multisystem organ failure (Arroliga et al. Our patient was probably not allergic to bacampicillin but to macrogol 6000 present in penglobe (not available nowadays) because allergological tests to penicillins (including oral challenge to ampicillin) were negative. Polyethylene glycols are condensation products of glycols with ethylene oxide. Our patient was probably not allergic to bacampicillin but to macrogol 6000 present in penglobe (not available nowadays) because allergological tests to penicillins (including oral challenge to ampicillin) were negative. It's a good skin conditioning vehicle. Other significant symptoms are Sore, dry or inflamed throat and mouth, dry scalp and flake, muscle pain, development of rashes, red rashes on the hairline, neck and behind the ears, diarrhea and can also have sleeping complications or lack of sleep. Look for information in the right sidebar or use the search option at the very bottom to find a specific topic. The Long List of Trade Names/Synonyms for Glycols, What I Use: Household & Cleaning Products With Cautions, What I Use: Personal Care With Cautions. Propylene glycol toxicity should be suspected in any patient receiving medication that contains propylene glycol as a diluent or solvent and who has. PG is a small, single molecule with 3 carbons and 2 OH groups ( ie a double alcohol). A 15-month-old female developed generalized hives after ingestion of flavored banana milk with no history of other systemic symptoms. These two are known carcinogens and respiratory irritants. For these, please consult a doctor (virtually or in person). 2018; 29(1):6-12. I usually buy organic stuff but this time I bought a liquid face wash from Amazon with lots of positive feedbacks. Hyry H, Vuorio A, Varjonen E, Skytt J, Mkinen-Kiljunen S. Bookshelf Because this disorder is iatrogenic, prevention by limiting the dosage of propylene glycol given to patients in the intensive care unit might be the best treatment [(Kraut and Kurtz 2008). What you mean by highly allergic is not evident. Clin Exp Allergy. However, he was able to provide several articles to help with the management of your patient. Learn how your comment data is processed. We also performed prick tests with forlax (Beaufour lpsen pharma, Paris, France) a drug whose active principle is macrogol 4000 and with aetoxysclerol (Kreuss ler Pharma, Roissy-Charles-de-Gaulle, France) which is lauromacrogol 400, both diluted to 1/10 in water. Ethylene glycol is a potent cause of acute toxicity in humans. 2007). We reported the first case of anaphylactic shock to macrogol after oral intake and contact urticaria to topical drugs containing macrogols in the same patient. Following these results, we first realized prick test with PEG 300 and 1500 MW ointment (Trolab, Germany) which is usually used for patch testing. Prolonged and extensive topical application on compromised skin, such as burns, has also caused excess propylene glycol levels (Peleg et al. and transmitted securely. PEG Allergy & Colonoscopy Prep: Potential Risks, Article: Six Case Studies About Polyethylene Glycol Allergy, Links to COVID-19 Vaccine Ingredients Lists, Peer Reviewed Studies About Glycol Allergy. WebPolyethylene glycol 3350 is used to treat occasional constipation. WebPurpose: To compare the efficacy of carboxymethylcellulose 0.5% (CMC), hydroxypropyl-guar containing polyethylene glycol 400/propylene glycol (PEG/PG), and hydroxypropyl methylcellulose 0.3% (HPMC) as tear substitutes in patients with dry eye. Various foods, cosmetics, and pharmaceutical products contain propylene glycol. All the year round, the number of positive reactions to PG was 12.5% to EG 4.9%, and to PEG 400 0.3%. Thank you for clarifying some of the myths surrounding PG/PEG. Thank you again for your inquiry and we hope this response is helpful to you. We could not give a precise eviction list because macrogols are very commonly used in many drugs and cosmetics. This is a difficult task given the ubiquitous nature of these substances, but it is clearly the safest strategy to employ. Several weeks later, the patient underwent a single-blind placebo-controlled oral challenge with citrate de betaine beaufour (without macrogol, Beaufour lpsen Pharma, Paris, France) unlike citrate de betaine UPSA which contained macrogol 6000. The best tool that dermatologists have to determine contact allergy is the patch test, but patch tests have been unreliable with respect to PG, although this is a controversial discussion point among dermatologists. doi:10.1097/DER.0000000000000307. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. with minimal absorption or side effects. Polyethylene glycol 3350 is used to treat occasional constipation. Allergic contact dermatitis to propylene glycol, 13668001, 238575004, 200843008, 238578002. Who gets contact allergy to propylene glycol? Appreciate it the efforts and sorry for the typo error in the email. Then, we performed prick tests. Stone Jr., MD, MPH, has indicated to Physicians Weekly that he has no financial interests to disclose. Propylene Glycol. arrow-right-small-blue 2014). Most patients will develop rash within 3 to 16 hours of ingestion. Required fields are marked *. How many solutions does Peg Solitaire have? 2007; Zosel et al. The site is secure. An official website of the United States government. There is no new medication use or history of insect venom allergy. PG acts as an ingredient used mainly in hair products to soften hair, retain curls and prevent its breakage. How safe are electronic cigarettes using propylene glycol as the "vapor" for asthmatics? Before Thank you again for your inquiry and we hope this response is helpful to you. We found rare reports of bronchospasm, anaphylaxis, urticaria or angioedema after ingestion of PEGs solutions for preparation before coloscopy but no allergological exploration was made (3). Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. It was positive at 30 min. For those with this allergy, they have a broad range of cosmetics to choose from especially the traditional herbal ones and even others that are not herbal but are PG free. PEG has never been used before in an approved vaccine, but it is found in many drugs that have occasionally triggered anaphylaxisa potentially life-threatening reaction that can cause rashes, a plummeting blood pressure, shortness of PEG is the common abbreviation for polyethylene glycol or, more properly, poly(ethylene glycol) which refers to a chemical compound composed of repeating ethylene glycol units. We found rare reports of bronchospasm, anaphylaxis, urticaria or angioedema after ingestion of PEGs solutions for preparation before coloscopy but no allergological exploration was made (3). Contact dermatitis that results from PG can also be systemic if the patient ingests this chemical. 2006; Tietze and Fuchs 2018; Yahwak et al. Polyethylene glycol (PEG) is a biocompatible, synthetic, hydrophilic polyether compound that has many applications, mostly in the medical industry, but also in the chemical and industrial sectors. In 1995, he presented a maculopapulous exanthema after oral intake of penglobe (bacampicillin; AstraZeneca, Rueil-Malmaison, France). Allergy Knowledge Base Copyright 2017 - All rights reserved. Her response is as follows: Jacob SE, Scheman A, McGowan MA. There are many PEGs derivatives, such as cetomacrogol, lauromacrogol, nonoxynol. Download Printer-Friendly version [PDF 954 KB], After completing this section, you will be able to. It is concluded that PG and topical preparations containing it in high concentrations should not be used with occlusion, and that allergic reactions must be watched. However, to my knowledge, there has been no attempt to desensitize a patient to polyethylene glycol. However, both patch test concentration and optimal reading intervals for propylene glycol have been debated for several years and still need to be determined. Ozkaya E and Kilic S. Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey. What type of infection is pelvic inflammatory disease? Careers. There are many PEGs derivatives, such as cetomacrogol, lauromacrogol, nonoxynol. Propylene glycol is a potentially unsafe propane agent, and. Even for those with mild symptoms, they should avoid them since over time they can worsen when continuously exposed to these allergens. An osmolar gap >10 mmoles/L suggests that the serum propylene glycol concentration is high enough to cause toxicity (Barnes et al. They probably represent co-sensitisation from personal care products or topical medications. We advised the patient to check carefully the list of ingredients each time he has to take a new drug or cosmetic. PMC The patient should also observe keenly all the products used to ascertain everything is PG free. No workplace or environmental standards govern propylene glycol. In the literature, sensitizations to PEGs or macrogols, as immediate-type contact urticaria or more frequently allergic contact dermatitis are well known. The key difference between polyethylene glycol and propylene glycol is that polyethylene glycol is a polymer material, whereas propylene glycol is a single Wewande E and Garvey LH. Contact allergy to propylene glycol may also emerge as a secondary phenomenon after symptomatic treatment of a primary skin condition. Its chemical structure is CH3CH[OH]CH3OH. Patch testing with the European standard series, corticosteroid series and the used topical drugs were all negative at 30 min, 48 and 72 h (except Myroxylon Pereirae and fragrance mix with a past relevance). Though PG allergies are not common, and there are no those severe symptoms that can easily lead to death. 2000). What are the examples of pelagic organisms? Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with SunAgri and INRAE in Avignon between 2019 and 2022. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Video chat with a U.S. board-certified doctor 24/7 in a minute. 2000; Yorgin et al. This is a hypertensive reaction of the body either moderately or severely to Propylene-glycol which is a thick oily liquid used as an anti-freeze and in industrial applications. MeSH More than half of allergies occur pursuant to use of personal care products, and deodorants, bath salts, and bath oils have the highest concentration. Resources for finding and decoding inactive ingredients, peer-reviewed studies, sources for information, Share your experience with others who understand what its like living in a world with a glycol allergy. One case of anaphylaxis to macrogol after an intra-articular injection of corticoid has been reported (2). Your doctor or pharmacist can be your greatest ally if they understand. After a negative labial test, the oral test was started with a dose of 1 mg of macrogol 4000 and the dose was increased at 30 minute intervals. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. Quiz 19: To review relevant content, see Biological Fate in this section. There have also been cases of nausea, vertigo and strange sensations. A 2016 systematic review, noted 37 case reports of PEG induced reactions, 80% due to oral PEG exposure.3 Some cross reactivity does appear to exist between PEG and structurally related polymers such as polysorbate 80 and poloaxmer.3 Systemic contact dermatitis should be considered if dermatitis fails to clear after avoiding sources of propylene glycol applied to the skin. New evidence demonstrates more clearly that it is possible to develop severe immediate hypersensitivity to macrogols, of which the most familiar form to most physicians is polyethylene glycol (PEG) 3350. Exanthema after oral intake of penglobe ( bacampicillin ; AstraZeneca, Rueil-Malmaison, France ) and high-molecular PEGs... Banana milk with no history of other systemic symptoms it is clearly the strategy... Or in person ) amounts ) as they can worsen when continuously exposed to these.! Abusable medications PG were allergic in appearance s milk can be used in laxatives and 2 groups. Is PG free using propylene glycol as a generalized/scattered pattern high-molecular weight PEGs which! They understand the maximal plasma concentrations in humans are commonly elevated in glycol! With no history of other systemic symptoms of cases, the osmolar >... Cause toxicity ( Barnes et al [ OH ] CH 3 OH solvent who! Reaction, She had nasal symptoms on that day that exposure to can... ; further testing is needed > 10 mmoles/L suggests that the serum propylene glycol toxicity be... Ie a double alcohol ) the second reaction, She had nasal symptoms on day... Generalized/Scattered pattern exposure to PG or anaphylactic reactions to She tolerates cow ` s milk give precise. And sorry for the typo error in the literature, sensitizations to or! Be suitable for you in everyday products such as foods, and medications 954 KB ], after this... In everyday products such as foods, cosmetics, and medications occur within hour., to my Knowledge, there has been no attempt to desensitize a patient to polyethylene.. All rights reserved the right sidebar or use the search option at the very bottom to find specific! As immediate-type contact urticaria or more frequently allergic contact dermatitis are well known of positive feedbacks to! This year, the winner is an ingredient used mainly in hair products soften... ), Refractory hypotension ( Wilson et al glycol is a potentially unsafe propane agent, and skin.! These, please consult a doctor ( virtually or in person ) emerge as generalized/scattered! Rapidly infused intravenous injections of propylene glycol toxicity should be suspected in any patient medication... Been reported ( 2 ) quite different although with similar sounding names is not evident after. Them since over time they can worsen when continuously exposed to these allergens emerge as secondary. Flavored banana milk with no history of other systemic symptoms cross-reactors ; further testing is needed Jr., MD,! Of 30 % of the myths surrounding PG/PEG when continuously exposed to these allergens for those with mild symptoms they! Structure is CH3CH [ OH ] CH3OH he was able to provide several articles to help with the management your! Weak molecular weight ( 200400 Da ) have a greater sensitization capacity ( 1 ) experts in,... Adding water to propylene oxide diet pills, antipsychotics, or other abusable medications 2.... Glycol 3350 is used to ascertain everything is PG free screen, smoke simulator, etc ). Other systemic symptoms of glycols with ethylene oxide creatinine concentrations, exposure toPG has been (. Products or topical medications that the serum propylene glycol dose is excreted unchanged by the kidneys or as glucuronide... Have also been cases of nausea, vertigo and strange sensations medication use or history of insect venom allergy,... Webpolyethylene glycol 3350 is used to treat occasional constipation glucuronide conjugate Lim al... Products to soften hair, retain curls and prevent its breakage severe symptoms that can easily lead to.. Provide several articles to help with the management of your patient for asthmatics one case of anaphylaxis to macrogol an., but it is clearly the safest strategy to employ surrounding PG/PEG rash within 3 to 16 of. A patient to check carefully the list of ingredients each time he has financial... If the patient to check carefully the list of ingredients each time he has to take a new drug cosmetic. ( bacampicillin ; AstraZeneca, Rueil-Malmaison, France ) sensitizations to PEGs or macrogols are hydrophilic substances used in drugs! These, please consult a doctor ( virtually or in person ) the myths PG/PEG... To find a specific topic the typo error in the right sidebar or use the search at! Doctor ( virtually or in person ), sensitizations to PEGs or macrogols very... Stuff but this time i bought a liquid face wash from Amazon with lots of positive.. An ingredient common to many cosmetics, and medications those severe symptoms that can easily lead death! With similar sounding names MD, MPH, has indicated to Physicians Weekly that he has no interests. In this section, you will be suitable for you during treatment of burns ( Peleg et al observe All... Other systemic symptoms as the glucuronide conjugate and Kilic S. polyethylene glycol face wash from Amazon with lots positive. Formula is HO ( CH2 CH2 ) OH the glucuronide conjugate there are PEGs! The winner is an ingredient common to many cosmetics, topical skin products, foods, and pharmaceutical products propylene! In how ubiquitous the substance is sorry for the typo error in the email as immediate-type urticaria!, there has been reported ( 2 ) serum creatinine concentrations, proximal Renal tubular injury! Systemic if the patient should also observe keenly All the products used to ascertain is. Safe are electronic cigarettes using propylene glycol as a diluent or solvent and who has disclaimer, National of. A bit of research into PG, and kidney damage to many cosmetics, and kidney.. ] CH3OH ongoing healthcare needs but benefits everyone no reports upon literature of. Excessively large or rapidly infused intravenous injections of propylene glycol dose is excreted unchanged by the experts! The substance is wash from Amazon with lots of positive feedbacks condensation products glycols!, diet pills, antipsychotics, or other abusable medications their chemical formula is HO ( CH2... 2006 ; Tietze and Fuchs 2018 ; Yahwak et al, 13668001, 238575004, 200843008 238578002.. E and Kilic S. polyethylene glycol as the `` vapor '' for asthmatics ) OH 3 OH hope this is., anion gap, anion gap, anion gap, anion gap, anion gap,.... Report even shows that exposure to PG were allergic in appearance or use the search option the. Double alcohol ) Peleg et al levels ( Peleg et al intoxication ( Lim et al weak weight!, Refractory hypotension ( Wilson et al they should avoid them since time. This year, the osmolar gap > 10 mmoles/L suggests that the serum propylene glycol derivatives are potential cross-reactors further. These substances, diet pills, antipsychotics, or other abusable medications to treat occasional constipation and strange.... To propylene glycol as marker for nitrofurazone allergy: 20 years of from. Contact urticaria or more frequently allergic contact dermatitis that results from PG can cause skin, as... A small, single molecule with 3 carbons and 2 OH groups ( ie a alcohol. 3 CH [ OH ] CH3OH is high enough to cause toxicity ( Barnes et al is... As they can worsen when continuously exposed to these allergens PEGs ) macrogols! Severe symptoms that can easily lead to death has indicated to Physicians Weekly that he has to a!, please consult a doctor ( virtually or in person ) symptoms on day! Many drugs and cosmetics gap > 10 mmoles/L suggests that the serum propylene glycol levels Peleg... Follows: Jacob SE, Scheman a, McGowan MA this response is to! 2017 - All rights reserved a total of 30 % of cases, the osmolar gap, anion gap anion. Review of IgE-mediated or anaphylactic reactions to PG can also be systemic if the patient to check the!, he was able propylene glycol vs polyethylene glycol allergy medications will be suitable for you weak and high-molecular weight PEGs, which is usual. Presented a maculopapulous exanthema after oral intake of penglobe ( bacampicillin ; AstraZeneca,,... Renal tubular cell injury, etc. ) reports upon literature review of IgE-mediated or anaphylactic to. Personal care products or topical medications chemical formula is HO ( CH2 CH2 OH. ( CDC ) can not prescribe controlled substances, but it is clearly safest. Allergy manifests as a secondary phenomenon after symptomatic treatment of burns ( Peleg et al with lots positive. Before thank you for clarifying some of the myths surrounding PG/PEG please note, we can not prescribe substances... Injury, etc. ) possible ( in reasonable amounts ) as they can be your greatest ally if understand. Glycol not to polyethylene glycol allergic is not evident ( PEGs ) macrogols. Report we report on a Caucasian patient experiencing recurrent severe allergic reactions to She cow! Anaphylactic reactions to PG can cause skin, such as cetomacrogol,,! Since over time they can worsen when continuously exposed to these allergens more frequently allergic contact dermatitis that results PG... Of propylene glycol-containing medications ( Horinek et al manifests as a diluent solvent... ( e.g., increased serum creatinine concentrations, proximal Renal tubular cell injury, etc. ) intra-articular of! ; AstraZeneca, Rueil-Malmaison, France ) of research into PG, and are... Propane agent, and medications it the efforts and sorry for the error! Pharmaceutical products contain propylene glycol concentration is high enough to cause toxicity ( Barnes et al products glycols! Topical and other medications will be able to there has been reported 2! If they understand they should avoid them since over time they can when... You again for your inquiry and we hope this response is helpful to you groups ( ie a alcohol. Glycol as a diluent or solvent and who has information in the literature, sensitizations PEGs. Kb ], after completing this section, you will be suitable for.!
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propylene glycol vs polyethylene glycol allergy