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This biotechnology company, which operates in hemophilia and ultra-orphan disease drug space, has seven approved treatments, a strong pipeline, and steadily growing revenue. There's some people who say that they're disappointed because a company got taken out because they'd rather own the company and profit from the growth of that company individually. It remains to be seen if the takeover rumors are just wishful thinking or will turn into reality. In early 2017, the rumor mill was spinning with whispers of Gilead (GILD) close to acquiring Incyte. Date Acquirer Co. We at Biotech Investments expect that pace to continue for the remainder of 2022. Biotech M&A - 2021 Deals Search for: Biotech M&A - 2021 Deals. In the business of drug development, deals can be just as important as scientific breakthroughs. Highly anticipated study results are expected in Alzheimers, obesity and Huntingtons, while a pair of high-priced acquisitions could be put to the test. Rumors again surfaced in 2016 that Roche would acquire BioMarin in a deal that could be in the range of $130 to $150 per share. Gene-editing company Crispr (NASDAQ:CRSP) has long been considered as a potential M&A target owing to its promising technology platform and its longstanding partnership with Vertex Pharma (NASDAQ:VRTX). Dan utilizes his experience reading and reviewing scientific literature to evaluate prospects for success. 2019 saw more than 25 acquisition deals executed in the biotech sector, of which 14 were billion-dollar deals. It is focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. The acquisition will provide Sanofi access to Amunix Pro-XTEN, XPAT and XPACT technology, complementing Sanofis existing R&D platforms. The stock has rallied from a little over $1 a share to a current price of $28.84, which represents an increase of over 2800% - a staggering number. Additionally, it has a robust gene therapy pipeline, targeting DMD, limb-girdle muscular dystrophies and several other indications. Is It Too Late to Buy Vertex Pharmaceuticals Stock? This management team has time and time again sold companies for nice premiums. Therefore, I am picking 5 best Mid-cap biotech acquisition targets in this post with deal value less than $10B each. Seagen has quite a few oncology drugs that would work well with the Bristol-Myers drugs. Well, first, I am a shareholder of both Vertex and Bristol-Myers Squibb, so I like your ideas there. Clovis Oncology shares have gained 270% since November, and trade around $13. This therapeutic has been licensed to Swiss pharma giant Novartis. Sold Pharsight Corporation to Tripos International: Mr. Rosen served on the Board of Directors of Pharsight Corporation. This would be a similar strategy Voce followed with Obagi. Last month, Adaptimmune announced that SPEARHEAD-1 trial evaluating afamitresgene autoleucel (afami-cel, formerly ADP-A2M4) in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) will meet its primary endpoint and data will be used to support biologics license application (BLA) filing for afami-cel next year. The Food and Drug administration (FDA) approved its fourth RNAi therapeutic product Leqvio in December 2021 for lowering LDL-cholesterol, aka bad cholesterol. Powered by Madgex Job Board Software. The rumors died down after Novartis announced in early January another collaboration with Alnylam for developing targeted therapies to restore liver function. Zacks Investment Research, Alnylam Pharmaceuticals, Inc. (ALNY) : Free Stock Analysis Report, Biogen Inc. (BIIB) : Free Stock Analysis Report, BioMarin Pharmaceutical Inc. (BMRN) : Free Stock Analysis Report, Adaptimmune Therapeutics PLC (ADAP) : Free Stock Analysis Report, CRISPR Therapeutics AG (CRSP) : Free Stock Analysis Report. Go and get our Biotech Investments HOT STOCK REPORT. The company has three marketed products and boasts of a vibrant pipeline, with a host of investigational therapeutics. Oncology and gene therapy were the subjects of acquisitions this year. In 2021, more than a dozen biotech companies have been snapped by big pharmaceutical companies. I'm not sure. Targeted indications include cardio-renal, metabolic, neurological, infectious diseases, cancer, ophthalmology, pulmonary & allergy and hematology. Many members of the management came from ALZA Corporation, which was one of the most successful mergers in the above list. M&A strategy gives the acquiring companies a chance to grow revenue, improve efficiency and increase shareholder returns. Dan Cohen is a partner at stockmatusow and entrepreneur in the fields of nanotechnology, medical diagnostics, and energy storage. Since then, Alnylam has received FDA approval for several drugs and has developed a robust development pipeline. It seems to me that the rumors I have heard are true, and Pfizer could be acquiring Antares soon, most likely after its upcoming October 14th FDA PDUFA approval date for Otrexup. The rumors on Obagi turned out to be correct, as the company was sold last. Freight. Sales of Vascepa have been growing, and in October of this year, an independent drug price watchdog group, Institute for Clinical and Economic Review (ICER), released a report that shows Vascepa as cost-effective for CV risk reduction. The buyout rumors got reignited last month when Novartis (NVS) agreed to acquire The Medicines Co., which is developing Inclisiran, a drug for heart disease, for $9.7 billion. BioPharma Dive is tracking these deals below. . All rights reserved. Today, you can download 7 Best Stocks for the Next 30 Days. To read this article on Zacks.com click here. One of the hot topics in the biopharmaceutical world are mergers & acquisitions (M&A). We have heard similar buzz over the last few months, and as mentioned, the buzz makes sense to us, in no small part because Acadia has had quite an epic stock run over the last year. Antares Pharma ( ATRS ) We first began to hear acquisition rumors in Antares in late 2011. Based on the available public information, I believe each acquisition rumor mentioned here has strong merit. Sold Inspire Pharmaceuticals to Merck & Co. (MRK): Mr. Adams served as President and Chief Executive Officer of Inspire Pharmaceuticals, Inc. Merck bought out Inspire for $430M, or a 26% premium over the current share price. 1. The Motley Fool has a disclosure policy. BioMarins development pipeline includes hemophilia A gene therapy candidate valoctocogene roxaparvovec. Aesther Healthcare Acquisition Corp and Ocean Biomedical, Inc. announced that AEHA has filed with the U.S. Securities and Exchange Commission a definitive proxy statement in connection with its proposed business combination with Ocean and with respect to the special meeting of Aesthers stockholders scheduled to be held on February 3, 2023. Specifically, Seagen has an anti-TIGIT antibody. The uptake of all these products has been good. Cost basis and return based on previous market day close. Ionis (NASDAQ:IONS) is commercial-stage biopharma developing RNA-targeted therapy using antisense technology that can control gene expression in a cell using antisense oligonucleotides (ASO). Leap Therapeutics, Inc. and Flame Biosciences, Inc. announced that the companies have entered into a definitive merger agreement pursuant to which Leap has acquired Flame and its assets, including FL-301, its clinical stage anti-Claudin18.2 monoclonal antibody, FL-302, its preclinical anti-Claudin18.2/CD137 bispecific monoclonal antibody, FL-501, its preclinical anti-GDF15 monoclonal antibody, and net cash of approximately $50 million as of December 31, 2022. BMRN briefly touched $100.13 on February 5, 2019. Enclose phrases in quotes. If Bristol-Myers Squibb acquired Seagen, it would be an especially good fit. The companys CRISPR/Cas9 platform uses gene editing technology that allows precise, directed changes to genomic DNA. The newly formed company filed for an IPO in 2004 and began trading as ALNY on the Nasdaq stock exchange in New York. Because Scott is not 'officially trained' in the markets, he see things outside the box, using his experience to provide clarity and alpha. Stay on top of what's happening at JPM. This developer of rare disease drug Soliris has been in acquisition crosshairs since 2016 - with Roche, Pfizer, Novartis and Amgen been reported as potential buyers. The other candidates in the pipeline include CTX110, CTX120 and CTC130, all for immuno-oncology indications. Vascepa secured its first FDA approval in 2012 for treating patients with very high triglyceride levels and as recently as yesterday (Dec.14) was approved for wider use, i.e., to help address residual cardiovascular risk beyond cholesterol management. Politics. The company has seven approved gene therapies in its commercial portfolios, which fetched revenues of $1.86 billion in 2021. The reason is that their deal is for an over the counter product that Pfizer has in its inventory. While oncology and immuno-oncology are the key areas of focus, treatments for rare diseases and gene-editing companies also promise potential, making them lucrative investment areas. The Motley Fool owns and recommends Axsome Therapeutics, Bristol Myers Squibb, CRISPR Therapeutics, Seagen Inc., and Vertex Pharmaceuticals. INCY has gained 43% year-to-date and trades around $91. "Human natural killer cell" [Micrograph]. Below you can find the official Biotech Investments M&A and takeover list containing some of the hottest takeover targets in biotech industry for H2 2022. Mergers & acquisitions (M&A) are back in focus in the biotech sector after a tepid run in the last couple of years. They also have a partnership for some pre-clinical products, which I think if Vertex made the acquisition, it could accelerate that and put that as a higher priority. AMAG Pharmaceuticals (Market Cap $0.7bn) US specialty firm AMAG Pharmaceuticals Inc. is viewed as an acquisition target for companies established in women's health - specifically Novartis AG - due to the potential of bremelanotide in hypoactive sexual desire disorder (HSDD). Copyright Making the world smarter, happier, and richer. Even with a market cap of over $2B, we feel Acadia could fetch as much as $6B if the FDA approves pimavanserin, which could happen in the next 6 to 8 months. ALXN is down 22% from its all-time high of $141.86, recorded on April 10, 2019, and trades around $110. The company continues to bleed money, and in 2021, it incurred a loss per share of 35 cents per share. Cellectis announced today that Cibus Global LLC and Calyxt, Inc. (NASDAQ: CLXT) (Calyxt), announced that Calyxt and Calypso Merger Subsidiary, LLC, a Delaware limited liability company and wholly-owned subsidiary of Calyxt, entered into an Agreement and Plan of Merger with Cibus and certain other parties named therein (the Merger Agreement), pursuant to which, subject to the terms and conditions thereof, Calyxt and Cibus will merge in an all-stock transaction. Antares pharma ( ATRS ) We first began to hear acquisition rumors in antares in Late.. 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